daily reminder that the boy you’re in love with at 16 probably won’t matter when you’re 25.
daily reminder that the math test you failed your freshman year of high school probably won’t matter when you’re graduating college.
daily reminder that the problems you’re facing today may seem like the worlds end, but they will not matter in a year.
daily reminder that you’re going to be okay.
everything is going to be okay.
Give your closest friend, or friends, a pizza your heart. Six of these pendants form a full, silver-plated pizza. Hung on a 22” chain. Sold on Etsy.
Spotted in Nashville. [x]
this was one of the best disney sequels srsly do not argue with me on this
With a bit more of a budget, it probably could have been a theatrical film from WDAS.
(Figure 1: Fluorescent labeling reveals mossy fibers (red) projecting from the dentate gyrus (green) into the CA2 subregion (orange). Credit: Keigo Kohara, RIKEN–MIT Center for Neural Circuit Genetics)
Novel combination of techniques reveals new details about the neuronal networks for memory
Learning and memory are believed to occur as a result of the strengthening of synaptic connections among neurons in a brain structure called the hippocampus. The hippocampus consists of five subregions, and a circuit formed between four of these is thought to be particularly important for memory formation. Keigo Kohara and colleagues from the RIKEN–MIT Center for Neural Circuit Genetics and RIKEN BioResource Center have now identified a previously unknown circuit involving the fifth subregion.
For a hundred years, memory research has typically focused on the main circuit, which projects from layer II of the entorhinal cortex via the dentate gyrus to subregion CA3 and then CA1. Subregion CA2 lies between CA3 and CA1 but its cells are less elaborate than those of its neighbors and were thought not to receive inputs from the dentate gyrus.
Kohara and his colleagues combined anatomical, genetic and physiological techniques to analyze the connections formed by neurons in the CA2 subregion of the hippocampus in unprecedented detail. First, they identified the CA2 subregion by examining the expression of three genes that encode proteins called RGS14, PCP4 and STEP using a fluorescent marker to label nerve fibers—a technique called fluorescent immunohistochemistry. They were surprised to discover that, contrary to expectations, CA2 neurons receive extensive inputs from cells in the dentate gyrus (Fig.1).
Sweet Photos of a Senior Golden Retriever Snuggling with Baby Chicks. Remember Champ, the happiest dog in the world? His owner, 21-year-old Candice Sedighan, just shared with us a new series of photos she’s taken of the adorable dog and his newfound friends. All Photos by Candice Sedighan via My Modern Metropolis ~ Older dogs are adorable, too.♥
Sitting Poses References
A superb fuck-ton of human pose references.